The Muncie station, located at 700 E. Wysor Street, was built in 1901 by the Cincinnati, Richmond and Muncie Railroad (CR&M), which was acquired by the Chesapeake and Ohio Railway (C&O) in 1910. The C&O ended passenger service to Muncie in 1949, but the station was used for freight service until 1950, when the Muncie Gear Works became its new tenant.
In 1973, Chessie System (which eventually became CSX Transportation) restored the station for passenger service so it could be used by Amtrak on the James Whitcomb Riley and George Washington routes (which eventually became the Cardinal). The station was again removed from passenger service when the Cardinal was rerouted after April 27, 1986.
The station was listed on the National Register of Historic Places on April 14, 1997.
Restoration of the station began in 2003 and involved replacing the original Ludowici tiles with new ones produced by the same manufacturer. The restoration was completed and the building reopened to the public on June 5, 2005.
The building is now used as a visitor center and office for the Cardinal Greenway recreation trail, which uses the former C&O right-of-way. On display inside are photos and artifacts from the region's railroad history as well as photographs of the surrounding communities. Although the former C&O track has since been removed, a second parallel track, now owned by the Norfolk Southern Railway, remains in operation; it is separated from the Cardinal Greenway trail by a safety fence.
